The tree · Window · Happens to the world · Could be decided within 1 to 5 years
A cell-rejuvenation treatment based on partial reprogramming is given to people in a registered trial
Partial reprogramming turns back the age markers of cells by briefly switching on the genes used to make stem cells, without erasing what the cell is. It has restored sight and extended life in mice and is the most-funded route to actually reversing rather than slowing aging. The first human trial is the point where it becomes a medicine rather than a lab result, and it has happened: the first participant was dosed in June 2026, in a safety trial for two causes of age-related vision loss.
The test: what counts as it having happened
A registered clinical trial (on clinicaltrials.gov or an equivalent registry) doses at least one human participant with a partial-reprogramming therapy, for any indication.
Settled by: The trial registry entry and the sponsor's announcement of first dosing
Happened, June 9th, 2026
Life Biosciences press release of 2026-06-09 announcing the first participant dosed in its Phase 1 trial of ER-100 (registry entry NCT07290244), with independent press coverage
Sources: lifebiosciences.com, globenewswire.com, clinicaltrials.gov
The odds, by how long I live
No number yet for this one.
What the ledger says about this step
- The first person was given a cell-rejuvenation treatment in a registered trial, which moves the treatment out of the laboratory 2026-09-19 Settled
Revisions
| Date | Field | From | To | Why |
|---|---|---|---|---|
| 2026-09-19 | resolved_links | https://www.lifebiosciences.com/life-biosciences-announces-first-patient-dosed-in-phase-1-trial-of-er-100-for-optic-neuropathies/; https://www.globenewswire.com/news-release/2026/06/09/3308634/0/en/life-biosciences-announces-first-patient-dosed-in-phase-1-trial-of-er-100-for-optic-neuropathies.html; https://clinicaltrials.gov/study/NCT07290244 | Every event marked as having happened now links to the record that settled it, so a reader can check the claim (site rule added September 19th, 2026). |
Notes
Drafted open on September 8th, 2026 and found resolved the same evening when checked under the verification rule, before any probability was estimated.
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The record itself is data/W-window.toml in the public repository.